Description
Product Characteristics: delta-2 antibody, GluD2 antibody, GLUR D2 antibody, GluR delta 2 antibody, GluR delta-2 subunit antibody, GLURD 2 antibody, GLURD2 antibody, Glutamate receptor delta 2 subunit antibody, Glutamate receptor ionotropic antibody, Glutamate receptor ionotropic delta 2 antibody, GRID 2 antibody, Grid2 antibody, GRID2_HUMAN antibody, MGC117022 antibody, MGC117023 antibody, MGC117024 antibody
Target Information: Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. [provided by RefSeq, Jul 2008]